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ProfAnna-Maria Botha-Oberholster

Professor

Genetics

Orcid identifier0000-0002-9868-1566
  • Professor
    Genetics

OVERVIEW

I have been intrigued by the coevolutionary arms race between host plants and aphids since I started my professional career 30 years ago. My first introduction to wheat was at the Weizmann Institute in Rehovot, Israel in the lab of Prof Dan Atsmon, after being awarded a Winter scholarship at this prestigious institution. Here, despite being completely out of my depth, I quickly learned about the complexity of the wheat genome and its resiliency as a cultivated crop. I subsequently visited the prestigious Salk Institute of Science, La Jolla, USA, where I was introduced to host-pathogen interactions at the Plant Genetics Department in the lab of Prof Christopher Lamb. Both these visits have helped to shape my scientific interests and cultivated my fascination with the intricacies that underpins host plant-aphid interactions. During my time abroad, I gained invaluable experience that would help me later in my scientific career, and this has made me an advocate for young scientists to broaden their horizons through international exposure and networking. I have been affiliated and worked at numerous institutions, both local and abroad, where I have collaborated with many scientists and built wonderful, long-term partnerships and friendships. These relationships were pivotal in broadening my perspective laterally, as evidenced by my research outputs. Presently I am affiliated to Stellenbosch University, hold a B rating from NRF with outputs exceeding two hundred, and have graduated many acclaimed scientists. I have been the recipient of several awards, including the Gold Medal of the South African Genetics Society and a member of the Academy of Sciences of South Africa (ASSAf), for which I feel immensely honored. Arguably, my most notable contributions to the scientific community to date are the production of many genomic resources and two patents. My research groups’ work has provided an improved understanding of the Russian wheat aphid genome regarding its structure and function; and gave us some insight into the mechanisms underpinning how aphid genes are regulated to enable “biotypification” (i.e., the acquisition of virulence against its host) within a noticeably short evolutionary time while reproducing only parthenogenetically. My humble beginnings growing up on a farm have instilled the desire to fulfil my societal obligations towards contributing to the alleviation of poverty and improving local food security. To address these needs, my group and I have developed drought tolerant GM wheat that we have provided to our industry partners; we are actively developing many drought-tolerant wheat and maize mutant lines; have collaborated with farming communities in assessing and improving their managed water resources for increased sustainability and lower maintenance; as well as striving towards finding innovative solutions in developing environmentally friendly and sustainable pest control measures.

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