Professor Wiysonge is a public health physician, epidemiologist, vaccinologist, implementation scientist, and globally recognised immunisation leader with more than 25 years of experience advancing immunisation programmes, evidence-informed policymaking, and health systems strengthening in Africa and globally.

He is an Extraordinary Professor of Global Health at Stellenbosch University and Honorary Professor at the South African Medical Research Council. He previously served as Team Lead for Vaccine-Preventable Diseases at the WHO Regional Office for Africa, where he led strategic and technical support for immunisation programmes across 47 countries, overseeing initiatives on routine immunisation, vaccine introduction, disease surveillance, outbreak response, and vaccine research and innovation.

Professor Wiysonge is one of Africa's most highly cited vaccine and immunisation researchers, with more than 500 peer-reviewed publications, over 130,000 citations, and an H-index of more than 100. His research has substantially influenced global and regional policies on vaccination, implementation science, and evidence-informed health decision-making. His work has informed recommendations and strategies of WHO, Africa CDC, national governments, and numerous international organisations.

He has served on several high-level scientific and policy advisory bodies, including - but not limited to - the WHO Strategic Advisory Group of Experts on Immunisation (SAGE), the African Advisory Committee on Health Research and Development (AACHRD), the WHO African Regional Immunization Technical Advisory Group (RITAG), South Africa's National Advisory Group on Immunisation (NAGI), Executive Board of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), Strategic Advisory Board of the European Integrated Services for Infectious Disease Outbreak Research (ISIDORe), Scientific Programme Committee of the International Conference on Public Health in Africa (CPHIA in 2026, 2025, 2024, 2023, and 2022)

His work is driven by a commitment to equity and the conviction that scientific evidence should translate into better health outcomes for all populations. Through research, policy engagement, and mentorship, he seeks to bridge the gap between evidence and action and contribute to stronger, more resilient, and more equitable health systems globally.